In vivo degradation behavior of porous composite scaffolds of poly(lactide-co-glycolide) and nano-hydroxyapatite surface grafted with poly(L-lactide)
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چکیده
منابع مشابه
Porous poly (D,L-lactide-co-glycolide) acid/biosilicate® composite scaffolds for bone tissue engineering.
This study evaluated the effects of the Biosilicate® and poly (D,L-lactic-co-glycolic) acid composites on bone repair in a tibial bone defect model in rats by means of using histological evaluation (histopathological and morphometric analysis) and gene expression analysis. Eighty male Wistar rats (12 weeks old, weighing ±300 g) were randomly divided into two groups: Biosilicate® group (BG) and ...
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please cite this article as : tavakoli-darestani r, kazemian gh, emami m, kamrani-rad a. poly (lactide-co-glycolide) nanofibers coated with collagen and nano-hydroxyapatite for bone tissue engineering. novel biomed 2013;1:8-15. background: a combination of polymeric nanofibrous scaffold and bioactive materials is potentially useful in bone regeneration applications. materials and methods: in th...
متن کاملPoly(lactide-co-glycolide)/Hydroxyapatite Porous Scaffold with Microchannels for Bone Regeneration
Mass transfer restrictions of scaffolds are currently hindering the development of threedimensional (3D), clinically viable, and tissue engineered constructs. For this situation, a 3D poly(lactide-co-glycolide)/hydroxyapatite porous scaffold, which was much favorable for transfer of nutrients to and waste products from the cells in the pores, was developed in this study. The 3D scaffold had an ...
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In vitro degradation behaviors of three-dimensional tissue engineering porous scaffolds made from amorphous poly(D,L-lactide-co-glycolide) with three different formulations have been systematically investigated up to 26 weeks in phosphate buffer saline solution at 37 degrees C. The following properties of the scaffolds were measured as a function of degradation time: dimensions, weight, compres...
متن کاملGrowth of continuous bonelike mineral within porous poly(lactide-co-glycolide) scaffolds in vitro.
Strategies to engineer bone have focused on the use of natural or synthetic degradable materials as scaffolds for cell transplantation or as substrates to guide bone regeneration. The basic requirements of the scaffold material are biocompatibility, degradability, mechanical integrity, and osteoconductivity. A major design problem is satisfying each of these requirements with a single scaffold ...
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ژورنال
عنوان ژورنال: Chinese Journal of Polymer Science
سال: 2014
ISSN: 0256-7679,1439-6203
DOI: 10.1007/s10118-014-1454-5